from German Federal Ministry of Economics and Technology.
Production of human monoclonal antibodies:
Mouse monoclonal antibodies have changed the face of immunology, but still there is a challenge to produce the human monoclonal antibodies as it is difficult to immunise the hman beings like mouse, therefore there is a need to develop in vitro immunisation methods of human B-lymphocytes. Peripheral blood is easily accessible source of B-lymphocytes, therefore Genekam Biotechnology AG has developed in vitro immunisation of B-lymphocytes of peripheral blood. Surely these methods can be used to in vitro immusiation of human B-lymphocytes of other sources like bone marrow, spleen, lymphnodes.
In vitro primary immunisation of human B-lymphocytes with different antigens e.g. viral, parasite bacterial antigens (primary immunisation): This technology offers a biggest advantage that one can immunise the lymphocytes with those antigens, which are toxic to human beings e.g. snake venom. This makes also possible to get the immunised lymphocytes against the diseases, which has been eradicated e.g. small pox or not present in one part of the world. One can do this method to get the immunised cells against the highly infectious agents, which are difficult to culture or there is a need to have high security laboratory. As we can stimulate the cells with killed (inactivated) agents. Therefore this method opens a new field to stimulate the lymphocytes against the new targets e.g. recently out broken swine flu H1N1 before it breaks out in vast way as this is happening at present. This method also opens a window to create entirely new antibodies, which are not known in the literature. This technology offers the possibility to create IgM antibodies too along with IgG production.
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SUD1 Genekam Immune B: Ready to use kit for in vitro immunisation of human B-lymphocytes of peripheral blood
against bacterial agents like Streptococcus, Borrelia burgdoferi Euro 299,- -
SUD2: Genekam S Immune A: Ready to use kit for in vitro immunisation of human B-lymphocytes of peripheral blood against
Autoantigens like cytokines, interleukins and other ligands call - SUD3 Genekam S Immune V: Ready to use kit for in vitro immunisation of human B-lymphocytes of peripheral blood against viral targets call
- SUD4 Genekam S Immune T: Ready to use kit for in vitro immunisation of human B-lymphocytes of peripheral blood against toxic targers call
- SUD5 Genekam P Immune B:Ready to use kit for in vitro primary immunisation of human B-lymphocytes of peripheral blood against bacterial targets call
- SUD6 Genekam P Immune A:Ready to use kit for in vitro primary immunisation of human B-lymphocytes of peripheral blood against autoantigens targets call
- SUD7 Genekam P Immune V:Ready to use kit for in vitro primary immunisation of human B-lymphocytes of peripheral blood against viral targets call
- SUD8 Genekam P Immune T:Ready to use kit for in vitro primary immunisation of human B-lymphocytes of peripheral blood against toxic targets call